DEMIGOD: Design and development of a sweat-based glucose monitoring graphene nanodevice (closed-loop) with controlled transdermal nanoemulsion release for hypoglycemic drug delivery


The present project aims to design and develop an innovative wearable device for the
prevention, diagnosis and treatment of diabetes mellitus which will make use of novice
graphene structures. The implementation of this task will rely on three individual actions and
more specifically:
A) The development of a very sensitive glucose bio-sensor based on graphene. Graphene
layers will be deposited layer-by-layer on a substrate (patch) with a cutting-edge
technology Langmuir Blogget based on which chemical compounds which can
sense/trace glucose will be immobilized to each graphene layer. This substrate will be a
sticker patch which will constantly count the glucose levels from sweat and consequently
will be a non-invasive diagnostic method.
B) The development of a release system for hypoglycemic treatment. Specific SGLT-2
inhibitors and GLP-1 analogues, that are commonly used for the treatment of T2DM, will
be encapsulated into a nanoemulsion. The nanoemulsion that poses lipophilic properties
will be then incorporated into a gelatine patch.
C) Development of α device/software which, through a Bluetooth technology, will receive
electrical signs from the bio-sensor, will analyze changes on the glucose levels from
sweat and trigger the release of the nanoemulsion from the patch via thermal heating.
The final product (Actions A, B and C) will be a product of a smart expertise in the area
of biomedicine and pharmacy which deploy the tremendous development of
biotechnology, computer science and material engineering in the last decade. The
implementation of this project is expected to contribute not only scientifically and
economically to the participating departments as well as the company and the country,
but mainly will contribute to the management of diabetes mellitus and the improvement
of the quality of life of the diabetic patients
The suggested effort of research is fully in line with the Research and Innovation Strategy for
Smart Specialization (RIS3) which aims to the development of new products for the prevention,
diagnosis and treatment of diseases.