DEMIGOD: Design and development of a sweat-based glucose monitoring graphene nanodevice (closed-loop) with controlled transdermal nanoemulsion release for hypoglycemic drug delivery
The present project aims to design and develop an innovative wearable device for theprevention, diagnosis and treatment of diabetes mellitus which will make use of novicegraphene structures. The implementation of this task will rely on three individual actions andmore specifically:A) The development of a very sensitive glucose bio-sensor based on graphene. Graphenelayers will be deposited layer-by-layer on a substrate (patch) with a cutting-edgetechnology Langmuir Blogget based on which chemical compounds which cansense/trace glucose will be immobilized to each graphene layer. This substrate will be asticker patch which will constantly count the glucose levels from sweat and consequentlywill be a non-invasive diagnostic method.B) The development of a release system for hypoglycemic treatment. Specific SGLT-2inhibitors and GLP-1 analogues, that are commonly used for the treatment of T2DM, willbe encapsulated into a nanoemulsion. The nanoemulsion that poses lipophilic propertieswill be then incorporated into a gelatine patch.C) Development of α device/software which, through a Bluetooth technology, will receiveelectrical signs from the bio-sensor, will analyze changes on the glucose levels fromsweat and trigger the release of the nanoemulsion from the patch via thermal heating.The final product (Actions A, B and C) will be a product of a smart expertise in the areaof biomedicine and pharmacy which deploy the tremendous development ofbiotechnology, computer science and material engineering in the last decade. Theimplementation of this project is expected to contribute not only scientifically andeconomically to the participating departments as well as the company and the country,but mainly will contribute to the management of diabetes mellitus and the improvementof the quality of life of the diabetic patientsThe suggested effort of research is fully in line with the Research and Innovation Strategy forSmart Specialization (RIS3) which aims to the development of new products for the prevention,diagnosis and treatment of diseases. Website: https://demigod.ece.uowm.gr/en/